3/4/2023 0 Comments Silk protein scaffold![]() ![]() Sofregen’s silk-based biostimulator filler consists of purified silk protein sponge particles mixed in cross-linked HA. Galderma and Sofregen plan to launch the development programs for all products imminently, with both companies looking to get the collaboration underway and bring the products to market as quickly as possible.Ībout Sofregen’s Silk technology platform This would grant Galderma all rights to the products being co-developed by the parties, as well as ownership of Sofregen’s silk technology platform in the aesthetic and dermatological field. Galderma will also have an exclusive option to acquire Sofregen’s Silk Voice ® as well as assets associated with its aesthetics business. Under the agreement, the companies will perform specified co-development activities related to a portfolio of novel silk-based biostimulator fillers, demonstrating Galderma’s commitment to deliver science-based innovation to the market. This agreement highlights Sofregen’s dedication to advancing the science of silk and will accelerate our ability to develop the next generation of biostimulator fillers with a recognized leader in this space.” "Galderma is a world leader in dermatology, with decades of experience in delivering cutting edge innovation in facial aesthetics and we are thrilled to have them as a partner. Naturally derived, silk has been shown to have unique properties for tissue support and regeneration, making it particularly well suited for facial aesthetic procedures. Sofregen’s pioneering silk technology combines silk protein with an HA carrier. Combining Galderma’s capabilities and scale with Sofregen’s novel silk platform represents a watershed moment for the aesthetics market through the development of a new category of biostimulator fillers designed to make an impact for healthcare professionals and their patients.” ![]() "At Galderma, we’re committed to advancing dermatology through constant innovation and joining forces with other industry pioneers. The novel platform harnesses the unique power of silk protein to enable immediate volume restoration and provide structure that facilitates new tissue generation. This collaboration will further expand Galderma’s capabilities built on decades of science-based aesthetics innovation and a unique heritage in biostimulator and hyaluronic acid (HA) fillers. LAUSANNE, Switzerland / Framingham, Massachusetts, U.S., Septem– Galderma, the world’s largest independent dermatology company, and Sofregen Medical, Inc., a medical device company pioneering the use of silk protein for tissue building and regeneration, announced today they have signed a co-development and option-to-acquire agreement. Agreement adds cutting-edge innovation to Galderma’s aesthetic injectable portfolio, the aesthetic industry’s broadest injectable range.Funding request for education and support activities.For healthcare professionals and customers.On the basis of these results, the fabricated membranes are potential candidates for skin tissue regeneration and wound healing application.Main navigation Toggle main menu visibility Overall, the membranes showed good antibacterial activity and biocompatibility. Attachment of cell with scaffolds was studied with Cell Attachment Assay and photos of cell attachment were recorded with SEM. To check the biocompatibility and cell toxicity, Alamar Blue Assay was performed. Antibacterial studies were carried out on S. For the biological use of as-prepared membranes, swelling and degradation studies in H 2O 2 and lysozyme were carried out. Membranes were characterized by FTIR and SEM. The membranes were fabricated in two series in first series concentration of TiO 2 was optimized only in silk in second series SF/CG/TiO 2 membranes were fabricated with two different concentrations of CG. mori, SF was extracted and regenerated which was used for further studies. Keeping in mind the properties of these materials, we designed SF/CG membranes loaded with TiO 2 particles for skin tissue regeneration using freeze drying technique. TiO 2 particles have antibacterial properties. Similarly, collagen (CG) is biocompatible and biodegradable protein-based natural polymer. Silk fibroin (SF) is a protein based mechanically strong, biocompatible, biodegradable, and permeable material which has been used in wide range of applications like cosmetics, foods, drugs, tissue engineering, and wound healing. However, a proper biocompatible, flexible, and mechanically stable, moisture retentive, and permeable synthetic membrane could be used instead of autografts. Although the autografts are considered as the gold standard, yet they have their own limitations. One of the biggest present challenges for clinicians is to regenerate the skin tissues which are lost due to trauma or diseases.
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